Rely-AMP FACTOR II

 

 

 

Venous Thromboembolism develops as the result of multiple interactions between non-genetic and genetic risk factors.Factor II G20210A mutation is frequent genetic risk factor involved in venous thromboembolism.

The factor II mutation (G20210A) is associated with increased plasma prothrombin levels and is present in 1% to 2% of the general population. Heterozygote carriers of the prothrombin G20210A mutation have an estimated 3 to 8-fold increased risk for venous thrombosis.

 

 

DETAILS

 

Rely-AMP FACTOR II is an in vitro Real Time polymerase chain reaction (RT- PCR) assay to detect mutations factor II. The assay allows for precise allelic discrimination of homozygous, heterozygous and wild type genotypes. Rely-AMP FACTOR II provides all necessary reagents for reliable extraction and DNA detection.

 

 

TECHNICAL SPECIFICATIONS

 

 

 

Quantitative/qualitative

 

Qualitative

 

Extraction

 

Magnetic Resin

 

 

Technology

 

 

Real time PCR

 

Sample type

 

Blood

 

Thermal cycler

 

optimized with CFX96 (Bio-Rad) but designed for use with real-time devices from various manufacturers

 

 

Fluorophore

 

 

FAM - TEXAX RED

 

Processing

 

Manual

Automated

 

Time to result

 

2 hours (after extraction)

 

 

 

PERFORMANCE

 

Diagnostic sensitivity:  > 94%

Diagnostic specificity: 100%

Analytical Specificity: no cross reazione

Analytical sensitivity: 10 copies plasmid

 

 

ORDERING INFORMATION

 

PRODUCT

CAT.NO.

PRICE

Rely-AMP FACTOR II extraction and detection kit

II50

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Rely-AMP FACTOR II detection kit

II50D

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