Rely-AMP MTHFR

Hyperhomocysteinemia is a risk factor for early-onset venous thrombosis. It can be caused by genetic defects in methionine-homocysteine metabolism. The thermolabile variant of methylene-tetrahydrofolate reductase (MTHFR), C677C>T (Ala222Val), is one of the most common genetic condition, which has been associated with mild to moderate hyperhomocysteinemia, and carriers of this variant are at increased risk of an early-onset stroke-like episode. Two common non-synonymous variants, the C677T (Ala222Val) and A1298C (Glu429Ala), were described for the MTHFR gene and associated with a decreased enzymatic activity and an alteration of intracellular folate distribution.

DETAILS

Rely-AMP MTHFR is an in vitro Real Time polymerase chain reaction (RT- PCR) assay to detect  mutations IN  MTHFR. The assay allows for precise allelic discrimination of homozygous, heterozygous and wild type genotypes.Rely-AMP MTHFR provides all necessary reagents for reliable extraction andDNA detection.

TECHNICAL SPECIFICATIONS

PERFORMANCE

Diagnostic sensitivity:  >94%

Diagnostic specificity: 100%

Analytical Specificity: no cross reazion

Analytical Sensitivity: 10 copies plasmid

ORDERING INFORMATION