Rely-AMP HPV 16-18

 

                                                                                                                                                                                                                         

 

Human papillomavirus (HPV) is a DNA virus, that is capable of establishing productive infections only in keratinocytes of the skin or mucous membranes. HPV infections are believed to cause 96% of cervical cancer. More than 120 genotypes of HPV have been identified, of these, 14 genotypes have been classified as “high-risk HPV” (HR-HPV) because they can lead to cervical cancer. Type 16 is the cause of approximately 50% of cervical cancers worldwide, and types 16 and 18 together account for about 70% of cervical cancers.

 

  

High Risk   HPV

Frequency   Europe (%)

16

58,1

18

15,7

 

 

 

 

 

  

DETAILS

 

Rely-AMP HPV is an in vitro polymerase chain reaction (PCR) assay for the direct, qualitative detection of HPV High Risk 16 and 18, from clinical specimens.

The kit is designed for the detection of the High Risk HPV DNA, based on the amplification of the specific sequence of the L1 region of Papilloma virus, by Real time PCR multiplex. The system has an internal control, based on amplification of Human RNase.

 

TECHNICAL SPECIFICATION

 

Quantitative/qualitative

Qualitative  

Extraction

Magnetic   resin

Technology

Multiplex   Real time PCR

Sample   type

PreservCyt medium

Thermal   cycler

Optimized with CFX96 (Bio-Rad) but designed for use with real-time devices from various manufacturers

Internal   control

RNasi gene

Positive   control

HPV plasmid   DNA

Fluorophore

FAM - HEX - CY5

Processing

Manual and  Automated

Time to result

2 hours   (after extraction)

 

 

PERFORMANCE

 

Diagnostic sensitivity: 98%

Diagnostic specificity: 100%

Analytical specificity: no cross-reaction

Analytical   sensitivity:

 

High Risk HPV

Copie/ml

16

300

18

500

 

 

 

 

 

ORDERING INFORMATION

 

PRODUCT

CAT.NO.

PRICE

Rely-AMP HPV

extraction and detection kit

16-18HPV 50

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Rely-AMP  HPV

detection kit

16-18HPV 50D

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