Rely-AMP FACTORS II/V

(multiplex PCR KIT)

Venous Thromboembolism develops as the result of multiple interactions between non-genetic and genetic risk factors.Factor V Leiden and factor II G20210A mutations are two frequent genetic risk factors involved in venous thromboembolism.

Individuals with factor V Leiden have a mutation at one of the arginine cleavage sites in factor V, such that factor V resists degradation by activated protein C. Persons who are heterozygous or homozygous for this disorder are 8 times and 80 times increased risk, respectively, for VTE.

The factor II mutation (G20210A) is associated with increased plasma prothrombin levels and is present in 1% to 2% of the general population. Heterozygote carriers of the prothrombin G20210A mutation have an estimated 3 to 8-fold increased risk for venous thrombosis.

DETAILS

Rely-AMP FACTORS II/V  is an in vitro Real Time polymerase chain reaction (RT- PCR) assay to detect mutations factor  II and V leiden. The assay allows for precise allelic discrimination of homozygous, heterozygous and wild type genotypes. Rely-AMP FACTORS II/V  provides all necessary reagents for reliable extraction and DNA detection.

TECHNICAL SPECIFICATIONS

PERFORMANCE

Diagnostic sensitivity:  >94%

Diagnostic specificity: 100%

Analytical Specificity: no cross reazione

Analytical Sensitivity: 10 copies plasmid

ORDERING INFORMATION